Department of Chemistry and Pharmacy, Food Chemistry Division, Emil Fischer Center, University of Erlangen-Nuremberg, Erlangen, Germany.
PLoS One. 2013;8(2):e55354. doi: 10.1371/journal.pone.0055354. Epub 2013 Feb 7.
Non-homeostatic hyperphagia, which is a major contributor to obesity-related hyperalimentation, is associated with the diet's molecular composition influencing, for example, the energy content. Thus, specific food items such as snack food may induce food intake independent from the state of satiety. To elucidate mechanisms how snack food may induce non-homeostatic food intake, it was tested if manganese-enhanced magnetic resonance imaging (MEMRI) was suitable for mapping the whole brain activity related to standard and snack food intake under normal behavioral situation. Application of the MnCl2 solution by osmotic pumps ensured that food intake was not significantly affected by the treatment. After z-score normalization and a non-affine three-dimensional registration to a rat brain atlas, significantly different grey values of 80 predefined brain structures were recorded in ad libitum fed rats after the intake of potato chips compared to standard chow at the group level. Ten of these areas had previously been connected to food intake, in particular to hyperphagia (e.g., dorsomedial hypothalamus or the anterior paraventricular thalamic nucleus) or to the satiety system (e.g., arcuate hypothalamic nucleus or solitary tract); 27 areas were related to reward/addiction including the core and shell of the nucleus accumbens, the ventral pallidum and the ventral striatum (caudate and putamen). Eleven areas associated to sleep displayed significantly reduced Mn2+ -accumulation and six areas related to locomotor activity showed significantly increased Mn2+ -accumulation after the intake of potato chips. The latter changes were associated with an observed significantly higher locomotor activity. Osmotic pump-assisted MEMRI proved to be a promising technique for functional mapping of whole brain activity patterns associated to nutritional intake under normal behavior.
非稳态性多食，是肥胖相关过度营养的主要原因之一，与饮食的分子组成有关，例如能量含量。因此，特定的食物，如零食，可能会引起与饱腹感无关的食物摄入。为了阐明零食如何引起非稳态性食物摄入的机制，研究人员测试了锰增强磁共振成像（MEMRI）是否适合在正常行为情况下映射与标准食物和零食摄入相关的全脑活动。通过渗透泵应用 MnCl2 溶液确保食物摄入不会因处理而受到显著影响。在进行 z 分数归一化和非仿射三维注册到大鼠脑图谱后，在自由进食的大鼠中，与标准饲料相比，薯片摄入后记录到 80 个预先定义的脑结构的灰度值存在显著差异，在组水平上。其中 10 个区域先前与食物摄入有关，特别是与多食（例如，下丘脑背内侧核或丘脑前室旁核）或饱食系统（例如，下丘脑弓状核或孤束核）有关；27 个区域与奖励/成瘾有关，包括伏隔核的核心和壳、腹侧苍白球和腹侧纹状体（尾状核和壳核）。与睡眠相关的 11 个区域显示 Mn2+ 积累明显减少，与运动活动相关的 6 个区域显示 Mn2+ 积累明显增加薯片摄入后。后者的变化与观察到的运动活性显著增加有关。渗透泵辅助 MEMRI 被证明是一种很有前途的技术，可用于在正常行为下对与营养摄入相关的全脑活动模式进行功能映射。
