Sheikh Emran S, Sheikh Ednan S, Fetterolf Donald E
Department of Clinical Medicine, Institute for Nerve, Hand & Reconstructive Surgery, Rutherford, NJ, USA.
Int Wound J. 2014 Dec;11(6):711-7. doi: 10.1111/iwj.12035. Epub 2013 Feb 15.
Non healing wounds present a significant social and economic burden. Chronic non healing wounds are estimated to affect as many as 1-2% of individuals during their lifetime, and account for billions of dollars of expense annually on both a national and global basis. Our purpose is to describe the use of a novel dehydrated amniotic membrane allograft (EpiFix(®) ; MiMedx Group, Inc., Kennesaw, GA) for the treatment of chronic non healing wounds. We describe the results of EpiFix treatment in four patients who had not achieved wound closure with both conservative and advanced measures, and had been referred for a definitive plastic surgery procedure. Healing was observed in a variety of wounds with one to three applications of the dehydrated amniotic membrane material. The material was well tolerated by patients. Healed wounds did not recur in long-term follow-up. Further investigation of the use of dehydrated amniotic membrane in broader application to various types of dermal wounds should be considered.
难愈合伤口带来了巨大的社会和经济负担。据估计，慢性难愈合伤口在人们一生中影响多达1%-2%的个体，在国家和全球范围内每年造成数十亿美元的费用。我们的目的是描述一种新型脱水羊膜同种异体移植物（EpiFix®；MiMedx Group, Inc., Kennesaw, GA）用于治疗慢性难愈合伤口的情况。我们描述了EpiFix治疗4例患者的结果，这些患者采用保守和先进措施均未实现伤口闭合，且已被转诊进行确定性整形手术。通过一至三次应用脱水羊膜材料，在多种伤口中观察到愈合情况。患者对该材料耐受性良好。在长期随访中，愈合的伤口未复发。应考虑进一步研究脱水羊膜在更广泛应用于各种类型皮肤伤口方面的用途。
