Department of Epidemiology and Biostatistics, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL 33199, USA.
Am J Public Health. 2013 Apr;103(4):717-26. doi: 10.2105/AJPH.2012.300930. Epub 2013 Feb 14.
We described the racial/ethnic disparities in survival among people diagnosed with AIDS in Florida from 1993 to 2004, as the availability of highly active antiretroviral therapy (HAART) became widespread. We determined whether these disparities decreased after controlling for measures of community-level socioeconomic status.
We compared survival from all causes between non-Hispanic Blacks and non-Hispanic Whites vis-a-vis survival curves and Cox proportional hazards models controlling for demographic, clinical, and area-level poverty factors.
Racial/ethnic disparities in survival peaked for those diagnosed during the early implementation of HAART (1996-1998) with a Black-to-White hazard ratio (HR) of 1.72 (95% confidence interval [CI] = 1.62, 1.83) for males and 1.40 (95% CI = 1.24, 1.59) for females. These HRs declined significantly to 1.48 (95% CI = 1.35, 1.64) for males and nonsignificantly to 1.25 (95% CI = 1.05, 1.48) for females in the 2002 to 2004 diagnosis cohort. Disparities decreased significantly for males but not females when controlling for baseline demographic factors and CD4 count and percentage, and became nonsignificant in the 2002 to 2004 cohort after controlling for area poverty.
Area poverty appears to play a role in racial/ethnic disparities even after controlling for demographic factors and CD4 count and percentage.
我们描述了 1993 年至 2004 年佛罗里达州艾滋病患者的生存种族/民族差异,因为高效抗逆转录病毒疗法(HAART)的广泛应用。我们确定在控制社区层面社会经济地位的衡量标准后,这些差异是否会减少。
我们通过生存曲线和 Cox 比例风险模型比较了非西班牙裔黑人和非西班牙裔白人间的全因生存情况,同时控制了人口统计学、临床和地区贫困因素。
在 HAART 早期实施期间(1996-1998 年),生存的种族/民族差异达到峰值,男性的黑人与白人的风险比(HR)为 1.72(95%置信区间[CI] = 1.62, 1.83),女性为 1.40(95% CI = 1.24, 1.59)。这些 HR 在 2002 年至 2004 年诊断队列中显著下降至男性 1.48(95% CI = 1.35, 1.64),女性则无显著下降至 1.25(95% CI = 1.05, 1.48)。在控制基线人口统计学因素和 CD4 计数和百分比后,男性的差异显著减少,但女性的差异不显著,而在控制地区贫困后,2002 年至 2004 年队列中的差异变得不显著。
即使在控制人口统计学因素和 CD4 计数和百分比后,地区贫困似乎也在种族/民族差异中发挥作用。