Department of Drug Sciences, University of Catania, Viale Andrea Doria n°6 95125 Catania, Italy.
Curr Med Chem. 2013;20(14):1847-57. doi: 10.2174/0929867311320140004.
NSAIDs are the most commonly prescribed category of drugs for the treatment of musculoskeletal pain and inflammation associated with many conditions. Topical administration of these drugs is always the best choice since adverse effects occur commonly with systemic NSAID therapy. Colloidal drug delivery systems (CDDS) are interesting systems, which are able to improve the duration of drug residence in the skin and to allow an achievable drug sustained and controlled release compared to conventional topical formulations. This review focuses on micro and nanoemulsions, vesicular carriers and nanoparticles as novel high efficiency delivery systems of NSAIDs in topical applications.
非甾体抗炎药（NSAIDs）是治疗与多种疾病相关的肌肉骨骼疼痛和炎症的最常用药物类别。由于全身性 NSAID 治疗常出现不良反应，因此局部给予这些药物始终是最佳选择。胶体药物递送系统（CDDS）是一种有趣的系统，与常规局部制剂相比，它能够提高药物在皮肤中的驻留时间，并实现药物的持续和控制释放。本综述重点介绍微乳液和纳米乳液、囊泡载体和纳米粒子作为 NSAIDs 在局部应用中的新型高效递药系统。
