National Influenza Centre, Department of Microbiological Diagnostics and Virology, Statens Serum Institut, Copenhagen.
Euro Surveill. 2013 Feb 7;18(6):20397.
In Denmark, the 2012/13 influenza season has been dominated by influenza A(H3N2). We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine by linking national registers in a test-negative case-control study of patients tested for influenza aged ≥65 years. The adjusted VE against laboratory-confirmed influenza A and B was -11% (95% CI: -41 to 14) and 69% (95% CI: 26 to 87), respectively. Genetic characterisation of the influenza A(H3N2) viruses indicated genetic drift, with seven substitutions at key antigenic sites.
在丹麦，2012/13 流感季节主要由甲型 H3N2 流感病毒引起。我们通过链接国家登记处，在≥65 岁的流感检测患者的病例对照研究中，估计了三价流感疫苗的疫苗效果（VE）。对实验室确诊的 A 型和 B 型流感的调整后 VE 分别为-11%（95%CI：-41 至 14）和 69%（95%CI：26 至 87）。对甲型 H3N2 流感病毒的遗传特征分析表明，病毒发生了遗传漂移，在关键抗原位点发生了 7 个突变。
