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营养与食品研究中的脂质组学。

Lipidomics in nutrition and food research.

机构信息

VTT Technical Research Centre of Finland, Espoo, Finland.

出版信息

Mol Nutr Food Res. 2013 Aug;57(8):1306-18. doi: 10.1002/mnfr.201200759. Epub 2013 Feb 15.

Abstract

Lipids are a diverse class of metabolites that play several key roles in the maintenance of human health. Lipidomics, which focuses on the global study of molecular lipids in cells, tissues, and biofluids, has been advancing rapidly over the past decade. Recent developments in MS and computational methods enable the lipid analysis with high throughput, resolution, sensitivity, and ability for structural identification of several hundreds of lipids. In nutrition research, lipidomics can be effectively used to elucidate the interactions between diet, nutrients, and human metabolism. Lipidomics can also be applied to optimize the effects of food processing on the dietary value, and in the evaluation of food-related health effects.

摘要

脂质是一类多样化的代谢产物,在维持人体健康方面发挥着几个关键作用。脂质组学专注于细胞、组织和生物体液中分子脂质的全面研究,在过去十年中发展迅速。MS 和计算方法的最新进展使能够以高通量、分辨率、灵敏度和对数百种脂质的结构鉴定能力进行脂质分析。在营养研究中,脂质组学可有效地用于阐明饮食、营养素和人体代谢之间的相互作用。脂质组学还可用于优化食品加工对膳食营养价值的影响,并评估与食品相关的健康影响。

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