Panthier Christophe, Querques Giuseppe, Zerbib Jennyfer, Souied Eric H
Department of Ophthalmology, University of Paris XII, Centre Hospitalier Intercommunal de Créteil, Créteil, France.
Ophthalmic Surg Lasers Imaging Retina. 2013 Mar-Apr;44(2):208-10. doi: 10.3928/23258160-20130213-01. Epub 2013 Feb 18.
The authors describe a case of combined full-thickness retinal and pigment epithelium macular hole that spontaneously developed in the right eye of an 86-year-old woman with age-related macular degeneration (AMD). One year prior, the patient had been diagnosed with drusenoid pigment epithelium detachment (PED) in the right eye and geographic atrophy in the left eye. Full-thickness macular hole associated with PED and spontaneous rip of the retinal pigment epithelium (RPE) associated with macular hole have been previously reported in eyes with exudative AMD. However, the authors are unaware of any report of spontaneous full-thickness retinal and pigment epithelium hole at the macula in AMD. The pathogenic mechanisms of this unusual macular hole, which involves the full retinal thickness and RPE, may include stretching forces at the vitreomacular interface and pushing from within the PED.
作者描述了一例86岁患有年龄相关性黄斑变性（AMD）的女性右眼自发形成的全层视网膜和色素上皮黄斑裂孔病例。一年前，该患者右眼被诊断为玻璃膜疣样色素上皮脱离（PED），左眼为地图样萎缩。先前已有渗出性AMD患者的眼睛出现与PED相关的全层黄斑裂孔以及与黄斑裂孔相关的视网膜色素上皮（RPE）自发撕裂的报道。然而，作者尚未知晓有关于AMD患者黄斑区自发全层视网膜和色素上皮裂孔的任何报道。这种累及整个视网膜厚度和RPE的不寻常黄斑裂孔的致病机制可能包括玻璃体黄斑界面的牵拉力和PED内部的推力。
