Heidarpour M, Mohri M, Borji H, Moghdass E
Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Vet Parasitol. 2013 Jul 1;195(1-2):131-5. doi: 10.1016/j.vetpar.2013.01.018. Epub 2013 Jan 30.
The objective of the present study was to evaluate the changes of antioxidants and oxidative stress markers in cattle with cystic echinococcosis (CE). Thirty cattle with liver CE along with 30 healthy cattle were used for the study. Parasitized cattle presented a significantly higher lipid peroxidation assessed by the malondialdehyde (MDA) compared with healthy animals (P<0.05). A significantly lower erythrocyte superoxide dismutase (SOD) and glucose 6-phosphate dehydrogenase (G6PD), and a significantly higher erythrocyte glutathione peroxidase (GPx) in the parasitized group, were observed when compared with healthy group (P<0.05). No significant differences were observed for serum total antioxidant status (TAS), zinc, copper and iron between parasitized and healthy groups. The results obtained in this study suggest that CE in cattle induces changes in the activity of antioxidant enzymes. These changes render host cells susceptible to oxidants and exaggerate the generation of free radicals with a consequent lipid peroxidation enhancement.
本研究的目的是评估患有囊型包虫病（CE）的牛体内抗氧化剂和氧化应激标志物的变化。选取30头患有肝脏CE的牛以及30头健康牛用于本研究。与健康动物相比，通过丙二醛（MDA）评估发现，感染寄生虫的牛脂质过氧化水平显著更高（P<0.05）。与健康组相比，感染组红细胞超氧化物歧化酶（SOD）和葡萄糖6-磷酸脱氢酶（G6PD）显著降低，而红细胞谷胱甘肽过氧化物酶（GPx）显著升高（P<0.05）。感染组与健康组之间的血清总抗氧化状态（TAS）、锌、铜和铁未观察到显著差异。本研究获得的结果表明，牛的CE会诱导抗氧化酶活性发生变化。这些变化使宿主细胞易受氧化剂影响，并加剧自由基的产生，从而增强脂质过氧化。
