Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Vet Parasitol. 2012 Jul 6;187(3-4):459-63. doi: 10.1016/j.vetpar.2012.01.015. Epub 2012 Jan 14.
Status of certain oxidative stress indices and zinc, copper and iron concentrations in blood were estimated in camel with liver cystic echinococcosis. In comparison to healthy control, the index of serum lipid peroxidation assessed by the malondialdehyde (MDA) level was significantly higher in the parasitized group. However, mean serum total antioxidant status (TAS) and erythrocyte glutathione peroxidase (GPx) were significantly lower in the parasitized group. Serum zinc concentration in camels with liver cystic echinococcosis was significantly lower than healthy control. In parasitized camels, a significant positive correlation of MDA with gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST) and bilirubin was observed. By contrast, MDA was inversely correlated with the values of packed cell volume (PCV), serum albumin and zinc. From the present study, it was concluded that cystic echinococcosis in camel is associated with oxidative stress. The resulting oxidative stress seems to have a role in the injury of hepatocytes, changes of trace elements and destruction of erythrocytes.
在患有肝包虫病的骆驼中，评估了某些氧化应激指标以及血液中锌、铜和铁浓度的状况。与健康对照组相比，寄生组的血清脂质过氧化指标（通过丙二醛（MDA）水平评估）显著升高。然而，寄生组的血清总抗氧化状态（TAS）和红细胞谷胱甘肽过氧化物酶（GPx）的平均值明显较低。患有肝包虫病的骆驼的血清锌浓度明显低于健康对照组。在寄生的骆驼中，丙二醛（MDA）与γ-谷氨酰转移酶（GGT）、天冬氨酸氨基转移酶（AST）和胆红素呈显著正相关。相比之下，MDA与红细胞压积（PCV）、血清白蛋白和锌的值呈负相关。从本研究可以得出结论，骆驼的包虫病与氧化应激有关。由此产生的氧化应激似乎在肝细胞损伤、微量元素变化和红细胞破坏中起作用。
