G 蛋白偶联受体在干细胞功能中的作用。
GPCRs in stem cell function.
机构信息
Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA.
出版信息
Prog Mol Biol Transl Sci. 2013;115:175-216. doi: 10.1016/B978-0-12-394587-7.00005-1.
Abstract
Many tissues of the body cannot only repair themselves, but also self-renew, a property mainly due to stem cells and the various mechanisms that regulate their behavior. Stem cell biology is a relatively new field. While advances are slowly being realized, stem cells possess huge potential to ameliorate disease and counteract the aging process, causing its speculation as the next panacea. Amidst public pressure to advance rapidly to clinical trials, there is a need to understand the biology of stem cells and to support basic research programs. Without a proper comprehension of how cells and tissues are maintained during the adult life span, clinical trials are bound to fail. This review will cover the basic biology of stem cells, the various types of stem cells, their potential function, and the advantages and disadvantages to their use in medicine. We will next cover the role of G protein-coupled receptors in the regulation of stem cells and their potential in future clinical applications.
摘要
许多身体组织不仅可以自我修复，还可以自我更新，这一特性主要归因于干细胞及其调控其行为的各种机制。干细胞生物学是一个相对较新的领域。虽然进展正在缓慢实现，但干细胞具有改善疾病和对抗衰老过程的巨大潜力，因此被推测为下一个灵丹妙药。在公众压力下，需要迅速推进临床试验，因此需要了解干细胞的生物学特性并支持基础研究计划。如果不了解成年期细胞和组织是如何维持的，临床试验肯定会失败。这篇综述将涵盖干细胞的基本生物学、各种类型的干细胞、它们的潜在功能，以及它们在医学中的优缺点。接下来，我们将介绍 G 蛋白偶联受体在干细胞调控中的作用及其在未来临床应用中的潜力。
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