Wang Xichun, Fu Xianghui, Van Ness Carl, Meng Zhipeng, Ma Xiaoxiao, Huang Wendong
Division of Cellular and Molecular Diabetes, Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute, City of Hope National Medical Center, 1500 E. Duarte Road, Duarte, CA 91010, USA.
Curr Pathobiol Rep. 2013 Mar 1;1(1):29-35. doi: 10.1007/s40139-012-0003-6. Epub 2012 Dec 21.
Liver cancer, particularly hepatocellular carcinoma (HCC), is the third leading cause of cancer death in the world. Bile acids (BAs) are liver-produced amphipathic molecules that are required to facilitate the absorption of cholesterol, fat-soluble vitamins, and lipids in the intestine. However, BAs are also known to act as potential carcinogens and deregulation of BA homeostasis has been linked to HCC formation. Two key BA receptors, farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), were recently identified, which provides great insights into BAs' normal physiological functions as well as their carcinogenic effects. In this review, we focus on the potential links among BAs, two BA receptors, and HCC. FXR and TGR5 not only play key roles in regulating BA homeostasis but also are essential in suppressing BAs' carcinogenic effects on liver cancer.
肝癌，尤其是肝细胞癌（HCC），是全球癌症死亡的第三大主要原因。胆汁酸（BAs）是肝脏产生的两亲性分子，有助于肠道中胆固醇、脂溶性维生素和脂质的吸收。然而，胆汁酸也被认为是潜在的致癌物，胆汁酸稳态失调与肝细胞癌的形成有关。最近发现了两种关键的胆汁酸受体，法尼醇X受体（FXR）和G蛋白偶联胆汁酸受体1（TGR5），这为胆汁酸的正常生理功能及其致癌作用提供了深入了解。在这篇综述中，我们关注胆汁酸、两种胆汁酸受体和肝细胞癌之间的潜在联系。FXR和TGR5不仅在调节胆汁酸稳态中起关键作用，而且在抑制胆汁酸对肝癌的致癌作用方面也至关重要。
