Gerber Jennifer Scotti, De Marchi Sara, Gaspert Ariana, Fehr Thomas, Cippà Pietro E
Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Faculty of Biomedical Science, Università della Svizzera Italiana, Lugano, Switzerland.
Case Rep Nephrol Dial. 2024 Aug 29;14(1):148-157. doi: 10.1159/000540294. eCollection 2024 Jan-Dec.
JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature.
We present 2 cases of JC-PVAN, both of which occurred >5 years after kidney transplantation. In both cases, transplant biopsies were performed because of worsening of kidney function. We found tubulitis and interstitial inflammation; immunohistochemistry was positive for SV40, but BK virus was not detected. The presence of JC virus confirmed the diagnosis of JC-PVAN. Immunosuppressive therapy was adopted, but in both cases graft function progressively deteriorated.
Our cases show that JC-PVAN, although much rarer than BK-PVAN, should be considered a possible cause of graft dysfunction even years after transplantation. Complete diagnostic workup, including kidney biopsy, is crucial for correct diagnosis and treatment.
JC多瘤病毒相关性肾病（JC-PVAN）是同种异体移植功能障碍的罕见原因，文献中仅描述了少数病例。
我们报告2例JC-PVAN，均发生在肾移植5年之后。两例均因肾功能恶化而行移植肾活检。我们发现了肾小管炎和间质炎症；免疫组化显示SV40呈阳性，但未检测到BK病毒。JC病毒的存在证实了JC-PVAN的诊断。采用了免疫抑制治疗，但两例移植肾功能均逐渐恶化。
我们的病例表明，JC-PVAN虽然比BK-PVAN罕见得多，但即使在移植多年后也应被视为移植功能障碍的可能原因。完整的诊断检查，包括肾活检，对于正确的诊断和治疗至关重要。
