Department of Ophthalmology, Rhode Island Hospital, Providence, Rhode Island, USA.
J Neuroophthalmol. 2013 Jun;33(2):165-8. doi: 10.1097/WNO.0b013e31828292b8.
A 63-year-old woman with a 1-month history of blurred vision in the right eye was found to have a right optic nerve sheath meningioma. She was treated with fractionated proton beam therapy using a total dose of 50.4 cobalt gray equivalent (CGE) in 1.8 CGE fractions, with subsequent improvement in vision. Twenty-seven months later, the patient reported a 6-week history of progressive blurred vision in her right eye. Magnetic resonance imaging revealed enhancement of the right optic nerve consistent with radiation optic neuropathy (RON). We are unaware of any previous reports of RON when radiotherapy doses fall within the current recommended guidelines of <55 CGE fractionated into daily doses <2 CGE.
一位 63 岁女性，右眼视力模糊病史 1 个月，被诊断为右侧视神经鞘脑膜瘤。她接受了分次质子束治疗，总剂量为 50.4 钴gray 等效（CGE），分为 1.8 CGE 分次，随后视力有所改善。27 个月后，患者报告右眼视力渐进性模糊 6 周。磁共振成像显示右侧视神经增强，符合放射性视神经病变（RON）。我们不知道在放疗剂量落在当前推荐的<55 CGE 分剂量<2 CGE 的范围内时，RON 是否有任何先前的报告。
