F -box 蛋白在病毒感染中的作用。
The Role of F-Box Proteins during Viral Infection.
机构信息
Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21944-970, Brazil.
出版信息
Int J Mol Sci. 2013 Feb 18;14(2):4030-49. doi: 10.3390/ijms14024030.
Abstract
The F-box domain is a protein structural motif of about 50 amino acids that mediates protein-protein interactions. The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. Several discoveries have been made on the use of the ubiquitin-proteasome system by viruses of several families to complete their infection cycle. On the other hand, F-box proteins can be used in the defense response by the host. This review describes the role of F-box proteins and the use of the ubiquitin-proteasome system in virus-host interactions.
摘要
F -box 结构域是一种约 50 个氨基酸的蛋白质结构基序，介导蛋白质-蛋白质相互作用。F-box 蛋白是 SCF（Skp1、Cullin、F-box 蛋白）复合物的四个组成部分之一，介导靶向蛋白酶体降解的蛋白质的泛素化，在许多细胞过程中发挥重要作用。已经发现几种病毒家族利用泛素-蛋白酶体系统完成其感染周期。另一方面，F-box 蛋白可以被宿主用于防御反应。本文综述了 F-box 蛋白在病毒-宿主相互作用中的作用以及泛素-蛋白酶体系统的利用。
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