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减肥和运动对肥胖人群血清中apelin 浓度和脂肪组织表达的影响。

Effects of weight loss and exercise on apelin serum concentrations and adipose tissue expression in human obesity.

机构信息

Department of Medicine, University of Leipzig, Leipzig, Germany.

出版信息

Obes Facts. 2013;6(1):57-69. doi: 10.1159/000348667. Epub 2013 Feb 21.

DOI:10.1159/000348667
PMID:23429279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5644751/
Abstract

OBJECTIVE

Apelin is an adipokine which plays a role in the regulation of glucose homeostasis and may contribute to the link between increased adipose tissue mass and obesity related metabolic diseases. Here we investigate the role of omental and subcutaneous (SC) adipose tissue apelin and its receptor APJ mRNA expression in human obesity and test the hypothesis that changes in circulating apelin are associated with reduced fat mass in three weight loss intervention studies.

METHODS

Apelin serum concentration was measured in 740 individuals in a cross-sectional (n = 629) study including a subgroup (n = 161) for which omental and SC apelin mRNA expression has been analyzed and in three interventions: 12 weeks exercise (n = 60), 6 months calorie-restricted diet (n = 19), 12 months after bariatric surgery (n = 32).

RESULTS

Apelin mRNA is significantly higher expressed in adipose tissue of patients with type 2 diabetes and correlates with circulating apelin, BMI, body fat, C-reactive protein, and insulin sensitivity. Obesity surgery-induced weight loss causes a significant reduction in omental and SC apelin expression. All interventions led to significantly reduced apelin serum concentrations which significantly correlate with improved insulin sensitivity, independently of changes in BMI.

CONCLUSIONS

Reduced apelin expression and serum concentration may contribute to improved insulin sensitivity beyond significant weight loss.

摘要

目的

Apelin 是一种脂肪因子，在调节葡萄糖稳态方面发挥作用，可能与脂肪组织质量增加和肥胖相关代谢疾病之间的联系有关。在这里，我们研究了内脏和皮下（SC）脂肪组织 Apelin 和其受体 APJ mRNA 表达在人类肥胖中的作用，并检验了以下假设，即循环 Apelin 的变化与三种减肥干预研究中脂肪量减少有关。

方法

在一项横断面（n = 629）研究中，我们测量了 740 个人的 Apelin 血清浓度，其中包括一个亚组（n = 161），已经分析了内脏和 SC Apelin mRNA 表达，并在三种干预措施中进行了研究：12 周运动（n = 60）、6 个月热量限制饮食（n = 19）和减肥手术后 12 个月（n = 32）。

结果

2 型糖尿病患者的脂肪组织中 Apelin mRNA 表达显著升高，与循环 Apelin、BMI、体脂肪、C-反应蛋白和胰岛素敏感性相关。肥胖手术引起的体重减轻导致内脏和 SC Apelin 表达显著降低。所有干预措施均导致 Apelin 血清浓度显著降低，与胰岛素敏感性改善显著相关，独立于 BMI 变化。

结论

Apelin 表达和血清浓度的降低可能有助于改善胰岛素敏感性，而不仅仅是体重显著减轻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a37/5644751/1a4ef81bbf5b/ofa-0006-0057-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a37/5644751/7523c1d6aea5/ofa-0006-0057-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a37/5644751/f0fd0d8b7c74/ofa-0006-0057-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a37/5644751/1a4ef81bbf5b/ofa-0006-0057-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a37/5644751/7523c1d6aea5/ofa-0006-0057-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a37/5644751/f0fd0d8b7c74/ofa-0006-0057-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a37/5644751/1a4ef81bbf5b/ofa-0006-0057-g03.jpg

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