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阿立哌唑改善阿斯伯格综合征的强迫症状。

Aripiprazole Improved Obsessive Compulsive Symptoms in Asperger's Disorder.

机构信息

Department of Child Adolescent Psychiatry, Çukurova University, Adana, Turkey.

出版信息

Clin Psychopharmacol Neurosci. 2011 Dec;9(3):134-6. doi: 10.9758/cpn.2011.9.3.134. Epub 2011 Dec 31.

DOI:10.9758/cpn.2011.9.3.134
PMID:23429759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3569112/
Abstract

There are many comorbid disorders associated with autism spectrum disorders in child and adolescent population. Although obsessive compulsive disorder and autism spectrum disorders (ASD) comorbidity has common in clinical practice, there are few reports about psychopharmacological treatment for obsessive compulsive symptoms in children with ASD in the literacy. We report a successful treatment case with aripiprazole in Asperger's Disorder with obsessive compulsive symptoms. The Yale Brown Obsessive Compulsive Scale was performed to assess symptom variety. This case report supports the effectiveness of aripiprazole in treatment of obsessive compulsive symptoms in Asperger's Disorder or ASDs. Aripiprazole may be beneficial to obsessive compulsive disorder comorbid autism spectrum disorders in child and adolescent age group.

摘要

在儿童和青少年人群中,自闭症谱系障碍常伴有许多共患疾病。虽然强迫症和自闭症谱系障碍(ASD)共病在临床实践中很常见,但关于自闭症谱系障碍儿童强迫症的精神药理学治疗的文献报道很少。我们报告了一例使用阿立哌唑成功治疗阿斯伯格障碍伴强迫症症状的病例。采用耶鲁-布朗强迫症量表评估症状的多样性。本病例报告支持阿立哌唑治疗阿斯伯格障碍或自闭症谱系障碍中强迫症症状的有效性。阿立哌唑可能对儿童和青少年自闭症谱系障碍共患强迫症有益。

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引用本文的文献

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Indian J Med Res. 2015 Sep;142(3):269-75. doi: 10.4103/0971-5916.166584.
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本文引用的文献

1
Successful treatment of comorbid obsessive-compulsive disorder with aripiprazole in three patients with bipolar disorder.在三位双相障碍患者中,阿立哌唑成功治疗了共病强迫症。
Gen Hosp Psychiatry. 2010 Sep-Oct;32(5):556-8. doi: 10.1016/j.genhosppsych.2010.07.004.
2
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).用于自闭症谱系障碍(ASD)的选择性5-羟色胺再摄取抑制剂(SSRI)
Cochrane Database Syst Rev. 2010 Aug 4(8):CD004677. doi: 10.1002/14651858.CD004677.pub2.
3
Aripiprazole in pervasive developmental disorder not otherwise specified and Asperger's disorder: a 14-week, prospective, open-label study.阿立哌唑治疗未另行规定的广泛性发育障碍和阿斯伯格障碍:一项为期14周的前瞻性开放标签研究。
J Child Adolesc Psychopharmacol. 2009 Jun;19(3):265-74. doi: 10.1089/cap.2008.093.
4
Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism.西酞普兰对患有自闭症谱系障碍且重复行为水平高的儿童无效:西酞普兰对自闭症儿童无效。
Arch Gen Psychiatry. 2009 Jun;66(6):583-90. doi: 10.1001/archgenpsychiatry.2009.30.
5
Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study.阿立哌唑对精神分裂症患者D(2)、5-HT(2)和5-HT(1A)受体占有率的差异效应:一项三重示踪正电子发射断层扫描研究
Am J Psychiatry. 2007 Sep;164(9):1411-7. doi: 10.1176/appi.ajp.2007.06091479.
6
Asperger's disorder and co-morbid bipolar disorder: diagnostic and treatment challenges.阿斯伯格综合征与共病双相情感障碍:诊断与治疗挑战
J Child Adolesc Psychopharmacol. 2007 Apr;17(2):247-55. doi: 10.1089/cap.2007.1723.
7
The Repetitive Behavior Scale-Revised: independent validation in individuals with autism spectrum disorders.重复行为量表修订版:在自闭症谱系障碍个体中的独立验证
J Autism Dev Disord. 2007 May;37(5):855-66. doi: 10.1007/s10803-006-0213-z.
8
The use of aripiprazole in obsessive-compulsive disorder: preliminary observations in 8 patients.阿立哌唑在强迫症中的应用:8例患者的初步观察
J Clin Psychiatry. 2005 Jan;66(1):49-51. doi: 10.4088/jcp.v66n0107.
9
The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder.成人自闭症谱系障碍中重复行为与生长激素对舒马曲坦激发试验反应之间的关系。
Neuropsychopharmacology. 2000 Feb;22(2):163-7. doi: 10.1016/S0893-133X(99)00121-9.
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Medication-induced hypomania in Asperger's disorder.阿斯伯格综合征中的药物性轻躁狂
J Am Acad Child Adolesc Psychiatry. 1999 Feb;38(2):110-1. doi: 10.1097/00004583-199902000-00003.