Department of Applied Physics, University of Eastern Finland, Kuopio, Finland.
PLoS One. 2013;8(2):e57117. doi: 10.1371/journal.pone.0057117. Epub 2013 Feb 19.
The non-invasive assessment of blood flow is invaluable for the diagnostic and monitoring treatment of numerous vascular and neurological diseases. We developed a non-invasive and non-contact method of blood pulsation imaging capable of visualizing and monitoring of the two-dimensional distribution of two key parameters of peripheral blood flow: the blood pulsation amplitude and blood pulsation phase. The method is based on the photoplethysmographic imaging in the reflection mode. In contrast with previous imaging systems we use new algorithm for data processing which allows two dimensional mapping of blood pulsations in large object's areas after every cardiac cycle. In our study we carried out the occlusion test of the arm and found (i) the extensive variability of 2D-distribution of blood pulsation amplitude from one cardiac cycle to another, and (ii) existence of the adjacent spots to which the blood is asynchronously supplied. These observations show that the method can be used for studying of the multicomponent regulation of peripheral blood circulation. The proposed technique is technologically simple and cost-effective, which makes it applicable for monitoring the peripheral microcirculation in clinical settings for example, in diagnostics or testing the efficiency of new medicines.
血流的无创评估对于许多血管和神经疾病的诊断和治疗监测都具有重要价值。我们开发了一种非侵入性和非接触式的血液搏动成像方法，能够可视化和监测外周血流的两个关键参数的二维分布：血液搏动幅度和血液搏动相位。该方法基于反射模式下的光体积描记成像。与以前的成像系统相比，我们使用新的数据处理算法，允许在每个心动周期后对大物体区域的血液搏动进行二维映射。在我们的研究中，我们进行了手臂的闭塞测试，发现 (i) 血液搏动幅度的二维分布在一个心动周期到另一个心动周期之间存在广泛的可变性，以及 (ii) 存在血液异步供应的相邻点。这些观察结果表明，该方法可用于研究外周血液循环的多组分调节。所提出的技术在技术上简单且具有成本效益，这使其适用于在临床环境中监测外周微循环，例如在诊断或测试新药的效率方面。
