茄科食用作物中药物蛋白的生产。
Production of pharmaceutical proteins in solanaceae food crops.
机构信息
Department of Agricultural Sciences, University of Naples "Federico II", Via Università 100, Portici 80055, Naples, Italy.
出版信息
Int J Mol Sci. 2013 Jan 29;14(2):2753-73. doi: 10.3390/ijms14022753.
Abstract
The benefits of increased safety and cost-effectiveness make vegetable crops appropriate systems for the production and delivery of pharmaceutical proteins. In particular, Solanaceae edible crops could be inexpensive biofactories for oral vaccines and other pharmaceutical proteins that can be ingested as minimally processed extracts or as partially purified products. The field of crop plant biotechnology is advancing rapidly due to novel developments in genetic and genomic tools being made available today for the scientific community. In this review, we briefly summarize data now available regarding genomic resources for the Solanaceae family. In addition, we describe novel strategies developed for the expression of foreign proteins in vegetable crops and the utilization of these techniques to manufacture pharmaceutical proteins.
摘要
提高安全性和成本效益的好处使得蔬菜作物成为生产和提供药物蛋白的合适系统。特别是，茄科可食用作物可以作为廉价的生物工厂，用于生产口服疫苗和其他可作为最小加工提取物或部分纯化产品摄入的药物蛋白。由于当今科学界可获得新型遗传和基因组工具的发展，作物植物生物技术领域正在迅速发展。在这篇综述中，我们简要总结了目前关于茄科植物基因组资源的数据。此外，我们还描述了为在蔬菜作物中表达外源蛋白而开发的新策略，以及利用这些技术制造药物蛋白的方法。
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