Bonner D P, Mechlinski W, Schaffner C P
J Antibiot (Tokyo). 1975 Feb;28(2):132-5. doi: 10.7164/antibiotics.28.132.
In solid form, amphotericin B and amphotericin B methyl ester free base exhibit similar stability. Acid salts of the methyl ester derivative stored under identical conditions are less stable. In solution, amphotericin B is generally more stable than its methy ester salts. However, when pH is adjusted to 6.0 and storage temperature held at 5 degrees C the methyl ester salts reflect the stability exhibited by the parent compound, amphotericin B.
在固体形式下，两性霉素B和两性霉素B甲酯游离碱表现出相似的稳定性。在相同条件下储存的甲酯衍生物酸盐稳定性较差。在溶液中，两性霉素B通常比其甲酯盐更稳定。然而，当pH值调至6.0且储存温度保持在5℃时，甲酯盐表现出母体化合物两性霉素B所具有的稳定性。
