CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.
Nat Rev Cancer. 2013 Apr;13(4):227-32. doi: 10.1038/nrc3483. Epub 2013 Feb 28.
Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment. However, the vast majority of the research into cancer metabolism has been limited to a handful of metabolic pathways, while other pathways have remained in the dark. This Progress article brings to light the important contribution of fatty acid oxidation to cancer cell function.
瓦伯格认为，他在癌细胞中观察到的代谢变化是由于线粒体功能障碍引起的。在过去的十年中，我们重新审视了这个观点，并对癌细胞的“代谢开关”有了更好的理解，包括癌症基因与代谢改变之间的密切因果关系，以及针对这些改变进行癌症治疗的潜力。然而，绝大多数癌症代谢的研究都局限于少数几种代谢途径，而其他途径仍然知之甚少。本文重点介绍了脂肪酸氧化对癌细胞功能的重要贡献。
