Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI ; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Epilepsy Curr. 2013 Jan;13(1):26-9. doi: 10.5698/1535-7511-13.1.26.
Cognitive impairment is a significant comorbidity of epilepsy. At present, the molecular/cellular mechanisms that underlie these cognitive impairments remain unknown. It seems likely that a complete understanding at the molecular/cellular level will require the use of rodent models. A number of rodent models of epilepsy are used to study cognition in a variety of behavioral tasks. This review presents a brief overview of two commonly used tasks (the Morris water maze and the radial arm maze) that have been used to assess spatial learning/memory in two chemoconvulsant models of temporal lobe epilepsy.
认知障碍是癫痫的一种严重合并症。目前，这些认知障碍的分子/细胞机制尚不清楚。似乎在分子/细胞水平上完全理解这些机制需要使用啮齿动物模型。目前有许多用于研究各种行为任务中认知的癫痫啮齿动物模型。本文简要概述了两种常用任务（Morris 水迷宫和放射臂迷宫），这两种任务已用于评估两种颞叶癫痫化学惊厥模型中的空间学习/记忆。
