空间学习和记忆——TLE 与之有何关系？
Spatial Learning and Memory-What's TLE Got To Do With It?
机构信息
Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, MI ; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
出版信息
Epilepsy Curr. 2013 Jan;13(1):26-9. doi: 10.5698/1535-7511-13.1.26.
Abstract
Cognitive impairment is a significant comorbidity of epilepsy. At present, the molecular/cellular mechanisms that underlie these cognitive impairments remain unknown. It seems likely that a complete understanding at the molecular/cellular level will require the use of rodent models. A number of rodent models of epilepsy are used to study cognition in a variety of behavioral tasks. This review presents a brief overview of two commonly used tasks (the Morris water maze and the radial arm maze) that have been used to assess spatial learning/memory in two chemoconvulsant models of temporal lobe epilepsy.
摘要
认知障碍是癫痫的一种严重合并症。目前，这些认知障碍的分子/细胞机制尚不清楚。似乎在分子/细胞水平上完全理解这些机制需要使用啮齿动物模型。目前有许多用于研究各种行为任务中认知的癫痫啮齿动物模型。本文简要概述了两种常用任务（Morris 水迷宫和放射臂迷宫），这两种任务已用于评估两种颞叶癫痫化学惊厥模型中的空间学习/记忆。
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本文引用的文献
1
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PLoS One. 2012;7(6):e38959. doi: 10.1371/journal.pone.0038959. Epub 2012 Jun 15.
2
Seizure-induced structural and functional changes in the rat hippocampal formation: comparison between brief seizures and status epilepticus.
Behav Brain Res. 2011 Dec 1;225(2):538-46. doi: 10.1016/j.bbr.2011.07.057. Epub 2011 Aug 5.
3
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PLoS One. 2011;6(7):e22372. doi: 10.1371/journal.pone.0022372. Epub 2011 Jul 26.
4
Future directions in the neuropsychology of epilepsy.
Epilepsy Behav. 2011 Sep;22(1):69-76. doi: 10.1016/j.yebeh.2011.06.004. Epub 2011 Jul 26.
5
IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy.
Exp Neurol. 2011 Oct;231(2):223-35. doi: 10.1016/j.expneurol.2011.06.014. Epub 2011 Jul 2.
6
The cognitive neuroscience of human memory since H.M.
Annu Rev Neurosci. 2011;34:259-88. doi: 10.1146/annurev-neuro-061010-113720.
7
The neurobiology of cognitive disorders in temporal lobe epilepsy.
Nat Rev Neurol. 2011 Mar;7(3):154-64. doi: 10.1038/nrneurol.2011.3. Epub 2011 Feb 8.
8
Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice.
Exp Neurol. 2009 Sep;219(1):284-97. doi: 10.1016/j.expneurol.2009.05.035. Epub 2009 Jun 3.
9
Complementary roles of hippocampus and medial entorhinal cortex in episodic memory.
Neural Plast. 2008;2008:258467. doi: 10.1155/2008/258467.
10
Remembrance of places you passed: social spatial working memory in rats.
J Exp Psychol Anim Behav Process. 2007 Jul;33(3):213-24. doi: 10.1037/0097-7403.33.3.213.
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