Wright R A, Miller S A, Corsello B F
Division of Gastroenterology, University of Louisville School of Medicine, Kentucky.
Gastroenterology. 1990 Jul;99(1):71-3. doi: 10.1016/0016-5085(90)91231-t.
Esophagobronchial reflexes have been demonstrated in both the cat and dog models. In order to determine if these reflexes are present in humans and if they are vagally mediated, a prospective sequential study was initiated. One hundred thirty-six individuals referred for esophageal manometric measurements were studied. Measurements of airway flow, arterial oxygen saturation, and pulse rate were performed before and after intraesophageal infusion of sterile water, normal saline solution, and 0.1 N hydrochloric acid. Highly significant reductions in heart rate, airway flow, and arterial oxygen saturation were noted after infusion of normal saline and 0.1 N hydrochloric acid compared with baseline water infusion (P less than 0.001). Graded responses were noted with heart rate: the more acidic the solution infused, the larger the decrement of heart rate. Atropine abolished postsaline/acid decrements of airway flow, arterial oxygen saturation, and heart rate. It is concluded that acid-induced, vagally mediated esophagobronchial reflexes are present in humans.
在猫和狗模型中均已证实存在食管支气管反射。为了确定这些反射在人类中是否存在以及是否由迷走神经介导，开展了一项前瞻性序贯研究。对136名因食管测压而转诊的个体进行了研究。在食管内注入无菌水、生理盐水和0.1N盐酸之前和之后，分别测量气道流量、动脉血氧饱和度和脉搏率。与注入基线水相比，注入生理盐水和0.1N盐酸后，心率、气道流量和动脉血氧饱和度显著降低（P小于0.001）。观察到心率呈分级反应：注入的溶液酸性越强，心率下降幅度越大。阿托品可消除注入盐水/酸后气道流量、动脉血氧饱和度和心率的下降。得出的结论是，酸诱导的、由迷走神经介导的食管支气管反射在人类中存在。
