Donnelly L, Mullin C, Balko J, Goldschmidt M, Krick E, Hume C, Brown D C, Sorenmo K
School of Veterinary Medicine, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania, Philadelphia, PA, USA.
Vet Comp Oncol. 2015 Mar;13(1):70-6. doi: 10.1111/vco.12021. Epub 2013 Mar 4.
Completeness of mast cell tumour (MCT) excision is determined by assessment of histologically tumour-free margins (HTFM). The HTFM width necessary to prevent local recurrence (LR), recognized as histologic safety margin (HSM) in human oncology, has not been defined. We hypothesized that HTFM width would correlate with risk for LR and high-grade tumours would require wider HTFM than low-grade tumours. Records of dogs with completely excised MCTs were included. Signalment, two-tier tumour grade, tumour size, HTFM width, recurrence and therapy data was collected. High-grade (n = 39) tumours were more likely to recur than low-grade (n = 51) tumours (35.9% versus 3.9%), P < 0.0001, with no association between HTFM width and LR. Twenty-nine percent of low-grade tumours had HTFM less than 3 mm; none recurred. Narrow (≤3 mm) histologic margins are likely adequate to prevent LR of low-grade tumours. High-grade tumours have significant risk of LR regardless of HTFM width.
肥大细胞瘤（MCT）切除的完整性通过对组织学上无肿瘤切缘（HTFM）的评估来确定。在人类肿瘤学中被视为组织学安全切缘（HSM）的预防局部复发（LR）所需的HTFM宽度尚未明确。我们假设HTFM宽度与LR风险相关，并且高级别肿瘤比低级别肿瘤需要更宽的HTFM。纳入了MCT完全切除的犬只记录。收集了信号、两级肿瘤分级、肿瘤大小、HTFM宽度、复发和治疗数据。高级别（n = 39）肿瘤比低级别（n = 51）肿瘤更易复发（35.9%对3.9%），P < 0.0001，HTFM宽度与LR之间无关联。29%的低级别肿瘤HTFM小于3毫米；无一复发。狭窄（≤3毫米）的组织学切缘可能足以预防低级别肿瘤的LR。无论HTFM宽度如何，高级别肿瘤都有显著的LR风险。
