Department of Oncology, Animal Referral Hospital Brisbane, Brisbane, Queensland, Australia.
Discipline of Veterinary Sciences, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Queensland, Australia.
Vet Comp Oncol. 2019 Sep;17(3):338-344. doi: 10.1111/vco.12477. Epub 2019 Apr 25.
The aim of this study was to identify patient and tumour factors most frequently associated with high histological grades of canine mast cell tumours (MCTs). Search criteria in a shared database of multiple Animal Referral Hospital locations within Australia generated 400 canine MCTs in 286 patients. Patient and tumour data were extrapolated and the association between a tumour being histologically high grade and patient and tumour factors, including: patient breed, patient gender and neuter status, patient age at MCT excision, tumour location and tumour size was assessed using univariate analysis. The study consisted of 90 (21.9%) tumours meeting histological high-grade criteria. Shar peis were the most likely breed to have high grade MCTs, whereas the Pug and the Golden Retriever were the least likely breeds to develop high-grade MCTs. No significant difference in risks could be established between the age at which the tumour was excised, or the gender and neuter status of patients. MCTs of the inguinal region were the most likely single location to be high grade. Tumour size did not influence the likelihood of a tumour being high grade or low grade. The results of this study suggest that patient and tumour factors may play a role in the histological grades of canine MCTs.
本研究旨在确定与犬肥大细胞瘤（MCT）高组织学分级最相关的患者和肿瘤因素。在澳大利亚多个动物转诊医院的共享数据库中进行搜索，生成了 286 名患者的 400 例犬 MCT。提取患者和肿瘤数据，并使用单因素分析评估肿瘤的组织学高分级与患者和肿瘤因素之间的关系，包括：患者品种、患者性别和绝育状态、MCT 切除时的患者年龄、肿瘤位置和肿瘤大小。该研究包括 90 例（21.9%）符合组织学高分级标准的肿瘤。设得兰牧羊犬是最有可能患有高分级 MCT 的品种，而哈巴狗和金毛寻回犬是最不可能发展为高分级 MCT 的品种。肿瘤切除时的年龄、患者的性别和绝育状态之间的风险无显著差异。腹股沟区的 MCT 是最有可能为高分级的单一部位。肿瘤大小不影响肿瘤为高分级或低分级的可能性。本研究结果表明，患者和肿瘤因素可能在犬肥大细胞瘤的组织学分级中起作用。
