School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Org Lett. 2013 Mar 15;15(6):1306-9. doi: 10.1021/ol4002448. Epub 2013 Mar 1.
Chemoselective hydrogenation of unsaturated compounds bearing an o-nitrobenzenesulfonyl (Ns)-amide moiety, affording the corresponding saturated compounds, was accomplished efficiently without loss of the nitro group by using the Pd/MS3A catalyst and a H2 balloon. Partial hydrogenation of alkynes bearing an Ns group to corresponding cis alkenes was achieved with the combination of the Pd/BN catalyst and an additive (diethylenetriamine or acetic acid).
通过使用 Pd/MS3A 催化剂和氢气气球，有效地实现了带有邻硝基苯磺酰基（Ns）酰胺部分的不饱和化合物的化学选择性加氢，得到相应的饱和化合物，而硝基基团不受损失。通过 Pd/BN 催化剂和添加剂（二乙烯三胺或乙酸）的组合，实现了带有 Ns 基团的炔烃的部分加氢，得到相应的顺式烯烃。
