通过信号动态对细胞信息进行编码和解码。
Encoding and decoding cellular information through signaling dynamics.
机构信息
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell. 2013 Feb 28;152(5):945-56. doi: 10.1016/j.cell.2013.02.005.
Abstract
A growing number of studies are revealing that cells can send and receive information by controlling the temporal behavior (dynamics) of their signaling molecules. In this Review, we discuss what is known about the dynamics of various signaling networks and their role in controlling cellular responses. We identify general principles that are emerging in the field, focusing specifically on how the identity and quantity of a stimulus is encoded in temporal patterns, how signaling dynamics influence cellular outcomes, and how specific dynamical patterns are both shaped and interpreted by the structure of molecular networks. We conclude by discussing potential functional roles for transmitting cellular information through the dynamics of signaling molecules and possible applications for the treatment of disease.
摘要
越来越多的研究表明，细胞可以通过控制其信号分子的时间行为（动态）来发送和接收信息。在这篇综述中，我们讨论了关于各种信号网络的动态及其在控制细胞反应中的作用的已知内容。我们确定了该领域正在出现的一般原则，特别关注刺激的身份和数量如何以时间模式编码，信号动态如何影响细胞结果，以及特定的动态模式如何受到分子网络结构的塑造和解释。最后，我们讨论了通过信号分子的动态传递细胞信息的潜在功能作用以及治疗疾病的可能应用。
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