Department of Dermatology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Am Acad Dermatol. 2013 Jul;69(1):61-5. doi: 10.1016/j.jaad.2012.12.975. Epub 2013 Feb 26.
The use of many of the standard skin-directed mycosis fungoides (MF) therapies on facial skin may be limited by site-specific increased risks of side effects, excessive inflammation, and ocular toxicity.
Our study aimed to describe the levels of erythema, scale, and induration of facial lesions in MF before and after low-dose high-dose-rate surface applicator brachytherapy and to examine the overall clinical response to brachytherapy.
A total of 23 facial MF lesions in 10 patients were treated with high-dose-rate brachytherapy doses of 4 Gy per session for a total of 2 fractions at our multidisciplinary cutaneous oncology clinic between August 17, 2009, and March 12, 2012.
In all 23 lesions, dramatic clinical improvement was observed. Patients were followed up for a median of 6.3 months. No recurrences were reported in the follow-up period.
Long-term follow-up is lacking. Reassessment of all included patients at annual intervals for a period of at least 5 years is the authors' goal.
Low-dose high-dose-rate brachytherapy using custom-made surface molds is a highly efficacious therapy in the treatment of facial lesions in MF.
许多标准的皮肤定向蕈样肉芽肿（MF）疗法在面部皮肤的使用可能受到特定部位增加副作用、过度炎症和眼毒性风险的限制。
我们的研究旨在描述 MF 面部病变在低剂量高剂量率表面敷贴器近距离放射治疗前后的红斑、鳞屑和硬结程度，并检查近距离放射治疗的总体临床反应。
在 2009 年 8 月 17 日至 2012 年 3 月 12 日期间，在我们的多学科皮肤肿瘤学诊所，10 名患者的 23 个面部 MF 病变接受了高剂量率近距离放射治疗，每次治疗剂量为 4Gy，共治疗 2 次。
所有 23 个病变均观察到明显的临床改善。患者的中位随访时间为 6.3 个月。在随访期间未报告复发。
缺乏长期随访。作者的目标是在至少 5 年内每年对所有纳入患者进行年度评估。
使用定制表面模具的低剂量高剂量率近距离放射治疗是治疗 MF 面部病变的一种非常有效的治疗方法。
