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社区居住人群晚年的功能恶化和功能改善的预后。

Prognosis for functional deterioration and functional improvement in late life among community-dwelling persons.

机构信息

Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, and Department of Physical Medicine and Rehabilitation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

出版信息

PM R. 2013 May;5(5):360-71. doi: 10.1016/j.pmrj.2013.02.008. Epub 2013 Feb 27.

Abstract

OBJECTIVE

To examine how health-related, socioeconomic, and environmental factors combine to influence the onset of activity of daily living (ADL) limitations or prognosis for death or further functional deterioration or improvement among elderly people.

DESIGN

A national representative sample with 2-year follow-up.

SETTING

Community-dwelling people.

PARTICIPANTS

Included were 9447 persons (≥70 years of age) in the United States from the Second Longitudinal Study of Aging who were interviewed in 1994, 1995, or 1996.

METHODS

Self- or proxy-reported health conditions, ADLs expressed as 5 stages describing severity and pattern of limitations, and other baseline characteristics were obtained. A multinomial logistic regression model was used to predict stage transitions. Because of incomplete follow-up (17.7% of baseline sample), primary analyses were determined by multiple imputation to address potential bias associated with loss to follow-up.

MAIN OUTCOME MEASUREMENT

ADL stage transitions in 2 years (death, deteriorated, stable, and improved ADL function).

RESULTS

In the imputed-case analysis, the percentages for those who died, deteriorated, were stable, and improved were 12.6%, 32.7%, 48.4%, and 6.2%, respectively. Persons at a mild stage of ADL limitation were most likely to deteriorate further. Persons at advanced stages were most likely to die. Married people and high school graduates had a lower likelihood of deterioration. The risk of mortality and functional deterioration increased with age. Certain conditions, such as diabetes, were associated both with mortality and functional deterioration; other conditions, such as cancer, were associated with mortality only, and arthritis was associated only with functional deterioration.

CONCLUSIONS

Although overlap occurs, different clinical traits are associated with mortality, functional deterioration, and functional improvement. ADL stages might aid physical medicine and rehabilitation clinicians and researchers in developing and monitoring disability management strategies targeted to maintaining and enhancing self-care among community-dwelling older people.

摘要

目的

探讨与健康相关的、社会经济的和环境因素是如何综合影响老年人日常生活活动(ADL)受限的发生或死亡或进一步功能恶化或改善的预后。

设计

具有 2 年随访的全国代表性样本。

设置

居住在社区的人群。

参与者

包括美国第二次老龄化纵向研究中的 9447 名(≥70 岁)参与者,他们于 1994 年、1995 年或 1996 年接受了访谈。

方法

通过自我或代理报告健康状况、ADL 表示为 5 个阶段,描述严重程度和受限模式,以及其他基线特征。使用多变量逻辑回归模型预测阶段转变。由于随访不完整(基线样本的 17.7%),主要分析通过多重插补来解决与随访丢失相关的潜在偏差。

主要结局测量

2 年内 ADL 阶段转变(死亡、恶化、稳定和改善 ADL 功能)。

结果

在插补病例分析中,死亡、恶化、稳定和改善的比例分别为 12.6%、32.7%、48.4%和 6.2%。处于 ADL 轻度受限阶段的人最有可能进一步恶化。处于晚期的人最有可能死亡。已婚人士和高中毕业生恶化的可能性较低。死亡和功能恶化的风险随着年龄的增长而增加。某些疾病,如糖尿病,与死亡率和功能恶化均相关;其他疾病,如癌症,仅与死亡率相关,关节炎仅与功能恶化相关。

结论

尽管存在重叠,但不同的临床特征与死亡率、功能恶化和功能改善相关。ADL 阶段可能有助于物理医学和康复临床医生和研究人员制定和监测针对维持和增强社区居住的老年人自我护理的残疾管理策略。

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