Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
J Clin Invest. 2013 Mar;123(3):973-9. doi: 10.1172/JCI64094. Epub 2013 Mar 1.
The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.
7 种哺乳动物的 Sirtuin 蛋白组成了一个保护性的酶骑兵，细胞可以调用这些酶来帮助抵御各种压力源。与衰老相关的病理学，如代谢综合征、神经退行性变和癌症，要么是由慢性应激引起的，要么是由慢性应激引起的。因此，激活 Sirtuin 蛋白可以提供一种治疗方法来缓冲慢性应激并改善与年龄相关的衰退。在这里，我们回顾了支持和反对这一观点的实验证据，以及同工型特异性 Sirtuin 激活对人类健康衰老的影响。
