Wei Ziyu, Yang Bo, Wang Huiyu, Lv Shuangjie, Chen Houzao, Liu Depei
State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.
Chin Med J (Engl). 2024 Apr 20;137(8):921-935. doi: 10.1097/CM9.0000000000003056. Epub 2024 Mar 25.
Caloric restriction (CR) is a well-established dietary intervention known to extend healthy lifespan and exert positive effects on aging-related diseases, including cardiovascular conditions. Sirtuins, a family of nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylases, have emerged as key regulators of cellular metabolism, stress responses, and the aging process, serving as energy status sensors in response to CR. However, the mechanism through which CR regulates Sirtuin function to ameliorate cardiovascular disease remains unclear. This review not only provided an overview of recent research investigating the interplay between Sirtuins and CR, specifically focusing on their potential implications for cardiovascular health, but also provided a comprehensive summary of the benefits of CR for the cardiovascular system mediated directly via Sirtuins. CR has also been shown to have considerable impact on specific metabolic organs, leading to the production of small molecules that enter systemic circulation and subsequently regulate Sirtuin activity within the cardiovascular system. The direct and indirect effects of CR offer a potential mechanism for Sirtuin modulation and subsequent cardiovascular protection. Understanding the interplay between CR and Sirtuins will provide new insights for the development of interventions to prevent and treat cardiovascular diseases.
热量限制（CR）是一种公认的饮食干预措施，已知其可延长健康寿命，并对包括心血管疾病在内的与衰老相关的疾病产生积极影响。沉默调节蛋白是一类依赖烟酰胺腺嘌呤二核苷酸（NAD+）的组蛋白脱乙酰酶，已成为细胞代谢、应激反应和衰老过程的关键调节因子，作为响应热量限制的能量状态传感器。然而，热量限制调节沉默调节蛋白功能以改善心血管疾病的机制仍不清楚。本综述不仅概述了最近研究沉默调节蛋白与热量限制之间相互作用的研究，特别关注它们对心血管健康的潜在影响，还全面总结了热量限制通过沉默调节蛋白直接介导对心血管系统的益处。热量限制还被证明对特定代谢器官有相当大的影响，导致产生进入体循环并随后调节心血管系统内沉默调节蛋白活性的小分子。热量限制的直接和间接作用为沉默调节蛋白的调节及随后的心血管保护提供了一种潜在机制。了解热量限制与沉默调节蛋白之间的相互作用将为预防和治疗心血管疾病的干预措施的开发提供新的见解。
