HC蓝1号和HC蓝2号的致突变性评估，II。对大鼠、小鼠、兔、仓鼠和猴原代肝细胞中DNA合成非预定诱导的影响。
Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, II. Effect on the in vitro induction of unscheduled DNA synthesis in rat, mouse, rabbit, hamster, and monkey primary hepatocytes.
作者信息
Hill L E, Parton J W, Probst G S, Garriott M L
机构信息
Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, Greenfield, IN 46140.
出版信息
Mutat Res. 1990 Jun;241(2):145-50. doi: 10.1016/0165-1218(90)90118-l.
2 hair dyes, HC Blue No. 1 and HC Blue No. 2, were evaluated for the in vitro induction of unscheduled DNA synthesis (UDS) in primary hepatocytes of rat, mouse, hamster, rabbit and monkey. NC Blue No. 1, which is identified as a carcinogen by the National Toxicology Program, induced UDS in all 5 systems. HC Blue No. 2, which is identified as a non-carcinogen, induced UDS in rat, mouse, hamster and rabbit primary hepatocytes. 3-Methylcholanthrene and methyl methanesulfonate were used as positive controls to determine the sensitivity of the test system.
对两种染发剂HC蓝1号和HC蓝2号进行了评估，以检测它们在大鼠、小鼠、仓鼠、兔子和猴子的原代肝细胞中体外诱导非程序性DNA合成（UDS）的情况。被美国国家毒理学计划认定为致癌物的HC蓝1号在所有5种体系中均诱导了UDS。被认定为非致癌物的HC蓝2号在大鼠、小鼠、仓鼠和兔子的原代肝细胞中诱导了UDS。使用3-甲基胆蒽和甲磺酸甲酯作为阳性对照来确定测试体系的敏感性。
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