Kelsey K T, Smith T J, Hammond S K, Letz R, Little J B
Laboratory of Radiobiology, Harvard School of Public Health, Boston, MA 02115.
Mutat Res. 1990 Jun;241(2):215-21. doi: 10.1016/0165-1218(90)90123-j.
Sister-chromatid exchanges (SCE) were measured in peripheral blood lymphocytes from 40 workers in the boat-building trade. Twenty of these workers were exposed to significant amounts of styrene. The mean air concentration of styrene in the breathing zone of the boat builders was 209 mg/m3 in the 7 exposed current smokers and 230 mg/m3 in the 13 exposed non-smokers. Urinary styrene metabolites were also measured and the mean mandelic acid/creatinine ratios in the exposed, smokers was 275 mg/g, and in the exposed, non-smokers 323 mg/g. The SCE frequency in lymphocytes from the styrene-exposed group did not differ from that in the controls, although smoking significantly induced SCE in these workers.
对40名造船行业工人外周血淋巴细胞中的姐妹染色单体交换（SCE）进行了检测。其中20名工人接触了大量苯乙烯。造船工人呼吸带空气中苯乙烯的平均浓度，在7名接触苯乙烯的现吸烟者中为209毫克/立方米，在13名接触苯乙烯的非吸烟者中为230毫克/立方米。还检测了尿中苯乙烯代谢物，接触苯乙烯的吸烟者中扁桃酸/肌酐的平均比值为275毫克/克，接触苯乙烯的非吸烟者中为323毫克/克。尽管吸烟显著诱导了这些工人的SCE，但苯乙烯接触组淋巴细胞中的SCE频率与对照组并无差异。
