Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Physiology (Bethesda). 2013 Mar;28(2):117-24. doi: 10.1152/physiol.00025.2012.
In recent years, obesity has been recognized as a major public health problem due to its increased prevalence in both children and adults and its association with numerous life-threatening complications including diabetes, heart disease, hypertension, and cancer. Obesity is a complex disorder that is the result of the interaction between predisposing genetic and environmental factors. However, the precise nature of these gene-gene and gene-environment interactions remains unclear. Here, we will describe recent studies demonstrating how fruit flies can be used to identify and characterize the mechanisms underlying obesity and to establish models of obesity-associated disorders.
近年来,肥胖症已被视为一个主要的公共卫生问题,因为它在儿童和成人中的发病率不断增加,并且与许多危及生命的并发症有关,包括糖尿病、心脏病、高血压和癌症。肥胖症是一种复杂的疾病,是易患遗传和环境因素相互作用的结果。然而,这些基因-基因和基因-环境相互作用的确切性质尚不清楚。在这里,我们将描述最近的研究,这些研究表明如何使用果蝇来鉴定和描述肥胖症的潜在机制,并建立与肥胖症相关的疾病模型。