Kelleher Maeve M, O'Carroll Michelle, Gallagher Aine, Murray Deirdre M, Dunn Galvin Audrey, Irvine Alan D, Hourihane Jonathan O'B
Department of Paediatrics and Child Health, University College Cork, Cork, Ireland.
Pediatr Dermatol. 2013 Nov-Dec;30(6):712-6. doi: 10.1111/pde.12106. Epub 2013 Mar 5.
Transepidermal water loss (TEWL) is a simple noninvasive measurement of inside-out skin barrier function. The goal of this research was to establish normal values for TEWL in early life using data gathered from the Cork BASELINE Birth Cohort Study. TEWL was recorded in a standardized fashion using a well-validated open-chamber system. A mean of three readings was recorded from 1,036 neonates (37-42 weeks gestational age) and 18 late preterm infants (34-37 weeks gestational age) within 96 hours of birth in an environmentally controlled room. Full-term neonatal TEWL measurements have a normal distribution (mean 7.06 ± 3.41 g of water/m(2) per hour) and mean preterm neonatal TEWL measurements were 7.76 ± 2.85 g of water/m(2) per hour. This is the largest evaluation to date of TEWL in a normal-term neonatal population. It therefore constitutes a reference dataset for this measurement using an open-chamber system.
经表皮水分流失（TEWL）是一种对皮肤屏障功能由内向外的简单非侵入性测量方法。本研究的目的是利用从科克基线出生队列研究收集的数据，确定生命早期TEWL的正常值。使用经过充分验证的开放式腔室系统以标准化方式记录TEWL。在环境受控的房间内，于出生后96小时内，对1036名新生儿（胎龄37 - 42周）和18名晚期早产儿（胎龄34 - 37周）进行了三次读数的平均值记录。足月新生儿的TEWL测量值呈正态分布（平均每小时7.06 ± 3.41克水/平方米），早产新生儿的TEWL测量平均值为每小时7.76 ± 2.85克水/平方米。这是迄今为止对正常足月新生儿群体TEWL进行的最大规模评估。因此，它构成了使用开放式腔室系统进行该测量的参考数据集。
