皮肤中的早期生命宿主-微生物相互作用。
Early life host-microbe interactions in skin.
机构信息
Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
出版信息
Cell Host Microbe. 2022 May 11;30(5):684-695. doi: 10.1016/j.chom.2022.02.016.
Our skin is the interface through which we mediate lifelong interactions with our surrounding environment. Initial development of the skin's epidermis, adnexal structures, and barrier function is necessary for normal cutaneous microbial colonization, immune development, and prevention of disease. Early life microbial exposures can have unique and long-lasting impacts on skin health. The identity of neonatal skin microbes and the context in which they are first encountered, i.e., through a compromised skin barrier or in conjunction with cutaneous inflammation, can have additional short- and long-term health consequences. Here, we discuss key attributes of infant skin and endogenous and exogenous factors that shape its relationship to the early life cutaneous microbiome, with a focus on their clinical implications.
我们的皮肤是我们与周围环境进行终身相互作用的界面。皮肤表皮、附属结构和屏障功能的最初发育对于正常的皮肤微生物定植、免疫发育和疾病预防是必要的。早期生活中的微生物暴露会对皮肤健康产生独特且持久的影响。新生儿皮肤微生物的特征以及它们首次出现的环境，即通过受损的皮肤屏障或以伴随皮肤炎症的形式出现，可能会带来短期和长期的健康后果。在这里，我们讨论了婴儿皮肤的关键属性以及塑造其与早期生活皮肤微生物组关系的内源性和外源性因素，重点讨论了它们的临床意义。
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