Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, Singapore.
Int J Biochem Cell Biol. 2013 Jun;45(6):1083-6. doi: 10.1016/j.biocel.2013.02.013. Epub 2013 Mar 1.
Adipose-derived stem cells (ASCs) are the mesenchymal stem cell (MSC) population found in the stromal-vascular fraction (SVF) of fat tissue. White adipose tissue (WAT), with well-established roles in lipid storage and adipokine secretion, is advantageous over bone marrow as the source of MSCs due to relative abundance and ease of isolation of the tissue. ASCs reside perivascularly within WAT and physiologically undergo adipogenesis to support WAT expansion in response to increased energy intake. Apart from adipogenesis, ASCs can be induced in vitro to differentiate into osteoblasts, chondroblasts, myocytes, neurons and other cell types. ASCs can also be reprogrammed to induced pluripotent stem (iPS) cells more efficiently than other cell types. ASCs are immunoprivileged cells and secrete immunomodulatory, angiogenic, anti-apoptotic and haematopoietic factors that facilitate tissue repair. The multi-lineage differentiation capacity, unique immunobiological properties and secretome of ASCs offer tremendous therapeutic potentials in regenerative medicine.
脂肪来源干细胞（ASCs）是存在于脂肪组织基质血管部分（SVF）中的间充质干细胞（MSC）群体。白色脂肪组织（WAT）在脂质储存和 adipokine 分泌方面具有明确的作用，作为 MSC 的来源优于骨髓，因为组织相对丰富且易于分离。ASCs 位于 WAT 的血管周围，生理上经历脂肪生成以支持 WAT 的扩张，以响应增加的能量摄入。除了脂肪生成，ASCs 可以在体外诱导分化为成骨细胞、软骨细胞、肌细胞、神经元和其他细胞类型。ASCs 也可以比其他细胞类型更有效地被重编程为诱导多能干细胞（iPS）细胞。ASCs 是免疫特权细胞，分泌免疫调节、血管生成、抗凋亡和造血因子，促进组织修复。ASCs 的多能分化能力、独特的免疫生物学特性和分泌组为再生医学提供了巨大的治疗潜力。
