Resch B A, Molnár G B, Papp G
Department of Obstetrics and Gynaecology, Albert Szent-Györgyi University Medical School, Szeged.
Ther Hung. 1990;38(1):30-6.
In a prospective study the effect of Betaloc therapy on pregnancy-associated mild and moderately severe hypertension has been examined. Besides the effects on the mother the changes of foetal heart rate were also observed. The antihypertensive therapy was performed with daily 3 x 100 mg (3 x 1 tab) oral doses of Betaloc in 30 pregnant women with 140-170 mmHg systolic and 90-110 mmHg diastolic blood pressure values at admittance. In the course of the examinations definite and statistically significant fall of systolic flood pressure could be observed following the onset of Betaloc therapy as early as on the first day of drug administration which could be maintained during therapy. Somewhat less definite but the same change was observed in the diastolic blood pressure. Maternal pulse rate was significantly higher before therapy than after finishing Betaloc therapy. Notable foetal bradycardia was not observed, in the course of Betaloc administration the decrease of foetal heart rate did not surpass the normal limit values. During the therapy no side-effect attributable to the drug was observed.
在一项前瞻性研究中，已对倍他乐克治疗妊娠相关轻度和中度严重高血压的效果进行了检查。除了对母亲的影响外，还观察了胎儿心率的变化。对30名入院时收缩压为140 - 170 mmHg且舒张压为90 - 110 mmHg的孕妇，采用每日口服3次、每次100 mg（3次、每次1片）倍他乐克进行抗高血压治疗。在检查过程中，早在给药第一天开始倍他乐克治疗后，即可观察到收缩压有明确且具有统计学意义的下降，且在治疗期间可维持。舒张压的变化虽不太明确但情况相同。母亲的脉搏率在治疗前明显高于倍他乐克治疗结束后。未观察到明显的胎儿心动过缓，在使用倍他乐克期间，胎儿心率的下降未超过正常极限值。治疗期间未观察到归因于该药物的副作用。
