Hamplová V, Monhart V, Zichová M
Vnitr Lek. 1989 Mar;35(3):256-63.
In six subjects the hypotensive action of metoprolol (Betaloc, Egis) after a dose of 166.7 +/- 47.1 mg and metipranolol (Trimepranol, Spofa) 21.7 +/- 3.7 mg was investigated. Betaloc influences after one month's administration the systolic blood pressure more effectively in a recumbent position and upright position and the diastolic pressure in a sitting position and after walking. The authors investigated also indicators of the circulation, blood sugar values, values of immunoreactive insulin, aldosterone and plasma renin activity after a single dose of 10 mg Trimepranol or 100 mg Betaloc. Betaloc caused a significant drop of the systolic blood pressure already after 15 minutes, Trimepranol after 30 minutes, in both instances the maximum effect was recorded after 45 minutes and persisted throughout the six-hour investigation. The diastolic blood pressure and heart rate were influenced only little. The blood sugar levels after Betaloc rose significantly during the first hour, after both drugs during the third hour. No correlation was found between changes of the blood sugar level and immunoreactive insulin levels. No differences were revealed as regards the effect on plasma renin activity and aldosterone levels.
对6名受试者研究了服用166.7±47.1毫克美托洛尔（倍他乐克，吉斯制药）和21.7±3.7毫克美替洛尔（三甲丙咪嗪，斯波法制药）后的降压作用。服用一个月后，倍他乐克在卧位和立位时对收缩压的影响更有效，在坐位和行走后对舒张压的影响更有效。作者还研究了单次服用10毫克三甲丙咪嗪或100毫克倍他乐克后循环指标、血糖值、免疫反应性胰岛素值、醛固酮和血浆肾素活性。服用倍他乐克15分钟后收缩压即显著下降，服用三甲丙咪嗪30分钟后收缩压显著下降，两种情况下45分钟后记录到最大效应，且在整个6小时的研究过程中持续存在。舒张压和心率仅受到轻微影响。服用倍他乐克后血糖水平在第一小时显著升高，服用两种药物后在第三小时血糖水平显著升高。未发现血糖水平变化与免疫反应性胰岛素水平之间存在相关性。在对血浆肾素活性和醛固酮水平的影响方面未发现差异。
