横纹肌抗体在副肿瘤环境中的表现。

Striational antibodies in a paraneoplastic context.

机构信息

Department of Medicine and Pathology, Mayo Clinic, Hilton 3-78, 200 First Street SW, Rochester, Minnesota 55905, USA.

出版信息

Muscle Nerve. 2013 Apr;47(4):585-7. doi: 10.1002/mus.23774. Epub 2013 Mar 5.

DOI:10.1002/mus.23774

PMID:23463255

Abstract

INTRODUCTION

The clinical significance of striational antibodies (StrAbs) detected in the course of paraneoplastic antibody testing is unknown.

METHODS

We compared all 203 striational antibody (StrAb)-seropositive patients identified (2004-2005) during evaluation for paraneoplastic antibodies with age- and sex-matched seronegative controls.

RESULTS

Thymoma and myasthenia gravis (MG) were significantly more common among cases (P<0.0001). Cancers more rarely detected after StrAb detection were adenocarcinoma in 5 patients and sarcoma in 3 patients. All patients who had a cancer identified after StrAb testing had a titer of ≥ 1:7680 or a coexisting muscle AChR-binding antibody. Autoimmune disorders more commonly observed among cases (with any StrAb value) included: hypothyroidism; rheumatoid arthritis; and pernicious anemia (all P<0.05).

CONCLUSIONS

StrAbs may serve as a diagnostic clue for an autoimmune diagnosis. There is a low likelihood of oncological significance in patients with StrAb titers <1:7680 without coexisting paraneoplastic Abs.

摘要

简介

在副肿瘤抗体检测过程中检测到的纹状体抗体（StrAbs）的临床意义尚不清楚。

方法

我们将在 2004-2005 年期间进行副肿瘤抗体评估时发现的所有 203 例纹状体抗体（StrAb）阳性患者（2004-2005 年）与年龄和性别匹配的血清阴性对照组进行比较。

结果

胸腺瘤和重症肌无力（MG）在病例中更为常见（P<0.0001）。在 StrAb 检测后更罕见检测到的癌症是 5 例腺癌和 3 例肉瘤。所有在 StrAb 检测后发现癌症的患者的滴度均≥1:7680 或同时存在肌肉 AChR 结合抗体。在病例中更常见观察到的自身免疫性疾病（具有任何 StrAb 值）包括：甲状腺功能减退症；类风湿关节炎；和恶性贫血（均 P<0.05）。