Department of Oncology, Hospital General Universitario Gregorio Marañon, C/Doctor Esquerdo, 46, 28007, Madrid, Spain.
Clin Transl Oncol. 2013 Sep;15(9):683-90. doi: 10.1007/s12094-013-1019-z. Epub 2013 Mar 5.
The reality of intraoperative radiation therapy (IORT) practice is consistent with an efficient and highly precise radiation therapy technique to safely boost areas at risk for local recurrence. Long-term clinical experience has shown that IORT-containing multi-modality regimens appear to improve local disease control, if not survival in many diseases. Research with IORT is a multidisciplinary scenario that covers knowledge from radiation beam adapted development to advance molecular biology for bio-predictability of outcome. The technical parameters employed in IORT procedures are important information to be recorded for quality assurance and clinical results analysis. In addition, specific treatment planning systems for IORT procedures are available, to help in the treatment decision-making process. A systematic revision of opportunities for research and innovation in IORT is reported including radiation beam modulation, delivery, dosimetry and planning; infrastructure and treatment factors; experimental and clinical radiobiology; clinical trials, innovation and translational research development.
术中放射治疗（IORT）实践的现实情况符合一种高效且高度精确的放射治疗技术，可安全地增强局部复发风险区域。长期的临床经验表明，包含 IORT 的多模式治疗方案似乎可以改善许多疾病的局部疾病控制，甚至提高生存率。IORT 研究是一个多学科的场景，涵盖了从辐射束适应性开发到先进分子生物学以实现结果生物预测性的知识。IORT 程序中使用的技术参数是用于质量保证和临床结果分析的重要信息。此外，还提供了专门用于 IORT 程序的特定治疗计划系统，以帮助治疗决策过程。本文报道了 IORT 研究和创新机会的系统审查，包括辐射束调制、传递、剂量测定和规划；基础设施和治疗因素；实验和临床放射生物学；临床试验、创新和转化研究发展。
