Hospital Universitari del Mar, Autonomous University of Barcelona, Barcelona, Spain.
J Assist Reprod Genet. 2013 Apr;30(4):479-85. doi: 10.1007/s10815-013-9962-8. Epub 2013 Mar 7.
To determine whether the use of Magnetic Activated Cell Sorting (MACS) as a sperm selection technique improves ART success rates in couples undergoing assisted reproduction treatment.
Systematic review and meta-analysis of prospective randomized trials. Two reviewers conducted study selection and data extraction independently.
Five studies (prospective randomized trials) that comprised 499 patients were included. Sperm selection using MACS resulted in statistically significant differences in pregnancy rates when compared with density gradient centrifugation and swim-up techniques (RR=1.50, 95 % CI 1.14-1.98). No differences were found between the groups according to the implantation (RR=1.03, 95 % CI 0.80-1.31) and miscarriage (RR=2.00, 95 % CI 0.19-20.90) rates.
MACS appears to be a safe and efficient method to select functional sperm with consistently good results. This technique may improve pregnancy rates when used to complement standard sperm selection methods in ART.
确定使用磁激活细胞分选（MACS）作为精子选择技术是否能提高接受辅助生殖治疗的夫妇的 ART 成功率。
对前瞻性随机试验进行系统评价和荟萃分析。两名审查员独立进行了研究选择和数据提取。
纳入了 5 项研究（前瞻性随机试验），共 499 名患者。与密度梯度离心和游泳技术相比，使用 MACS 进行精子选择在妊娠率方面具有统计学显著差异（RR=1.50，95%CI 1.14-1.98）。两组在着床率（RR=1.03，95%CI 0.80-1.31）和流产率（RR=2.00，95%CI 0.19-20.90）方面没有差异。
MACS 似乎是一种安全有效的方法，可以选择功能正常的精子，并且效果良好。该技术可通过补充 ART 中的标准精子选择方法来提高妊娠率。
