Skodová Z, Písa Z, Grafnetter D, Wiesner E, Cícha Z, Pikhartová J, Berka L, Vorlícek J, Emrová R, Vojtísek P
Institutu klinické a experimentální medicíny, Praha.
Cas Lek Cesk. 1990 Apr 13;129(15):452-6.
The authors followed up the development of serum cholesterol levels in the population aged 25-64 years in six districts of the CR. These districts collaborate since 1984 in the international WHO programme, MONICA. The mean total cholesterol levels increased during 1985-1988 in men from 6.21 mmol/l to 6.28 mmol/l (ns), in women from 6.18 mmol/l to 6.22 mmol/l (ns). During the same period in the population of the six districts the number of subjects with total cholesterol values of 5.2 mmol/l or less declined from 21.9% to 16.8% (p less than 0.001) in men and from 24.0% to 19.4% in women (p less than 0.01). It is important that the greatest change was recorded in the age group of 25-34 years--in men from 38.7% to 27.7% (p less than 0.01) and in women from 46.6% to 36.7% (p less than 0.05). In the investigated population in 1988 cholesterol levels of 6.5 mmol/l and more were recorded in 39.4% of the men and 36.9% of the women, values of 7.8 mmol/l and more in 10% of the men and 9.6% of the women. If in our population, within the framework of prevention of IHD, recommendations of the European Society for Atherosclerosis will be applied, preventive provisions will be necessary in more than 80% of the adult population.
作者对捷克斯洛伐克六个地区25至64岁人群的血清胆固醇水平变化进行了随访。自1984年以来,这些地区一直在与世卫组织的国际MONICA项目合作。1985年至1988年期间,男性的平均总胆固醇水平从6.21毫摩尔/升升至6.28毫摩尔/升(无显著差异),女性从6.18毫摩尔/升升至6.22毫摩尔/升(无显著差异)。在同一时期,六个地区人群中总胆固醇值在5.2毫摩尔/升及以下的男性人数比例从21.9%降至16.8%(p<0.001),女性从24.0%降至19.4%(p<0.01)。重要的是,25至34岁年龄组的变化最为显著——男性从38.7%降至27.7%(p<0.01),女性从46.6%降至36.7%(p<0.05)。1988年,在被调查人群中,39.4%的男性和36.9%的女性胆固醇水平达到6.5毫摩尔/升及以上,10%的男性和9.6%的女性胆固醇水平达到7.8毫摩尔/升及以上。如果在我国人群中,在预防缺血性心脏病的框架内应用欧洲动脉粥样硬化学会的建议,那么超过80%的成年人群将需要采取预防措施。