Teranishi Takaaki, Kageyama Masayuki, Kuwahara Shigefumi
Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Biosci Biotechnol Biochem. 2013;77(3):676-8. doi: 10.1271/bbb.120862. Epub 2013 Mar 7.
The spirocyclic pyrrole alkaloid, acortatarin A, which had been isolated from a Chinese medicinal plant, was synthesized from a known olefinic compound by a concise six-step sequence involving N-alkylation of a pyrrole derivative with an α-bromo ketone intermediate as the key step.
从一种中国药用植物中分离得到的螺环吡咯生物碱阿考他丁A，是由一种已知的烯烃化合物通过一个简洁的六步序列合成的，该序列以吡咯衍生物与α-溴代酮中间体的N-烷基化反应为关键步骤。
