Tu W
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990 Feb;23(1):27-30, 62-3.
The concentrations of HDL subfractions and apolipoprotein B were determined in 127 survivors of ischemic cerebrovascular disease (ICVD) confirmed by CT scanning. All these patients were classified into 3 groups according to the sites of the arterial lesion, the amount of infarction and the course of the disease. The levels of cholesterol in HDL subfractions (HDL2 and HDL3) were significantly reduced in the patient with ICVD. The level of ApoB was elevated significantly in these patients as compared with control group. No difference between acute stage group and recovery stage group was found on the levels of HDL subfractions and ApoB. It seemed that the abnormalities of the levels of HDL subfractions and ApoB might have existed prior to the onset of the stroke. It was found that the levels of HDL-C and HDL-C subfraction were significantly lower in the cortical artery group than in the perforating artery group. The amount of reduction of both HDL-C and HDL subfractions was inversely related to the size of the infarct volume in patients with ICVD. It was believed that the determination of concentration of HDL subfractions and ApoB and early correction of the ab-normality of lipoproteins metabolism might be of help in preventing or delaying the stroke.
通过CT扫描确诊的127例缺血性脑血管病（ICVD）幸存者的高密度脂蛋白亚组分和载脂蛋白B浓度进行了测定。所有这些患者根据动脉病变部位、梗死面积和病程分为3组。ICVD患者高密度脂蛋白亚组分（HDL2和HDL3）中的胆固醇水平显著降低。与对照组相比，这些患者的载脂蛋白B水平显著升高。急性期组和恢复期组在高密度脂蛋白亚组分和载脂蛋白B水平上未发现差异。似乎高密度脂蛋白亚组分和载脂蛋白B水平的异常可能在中风发作之前就已存在。发现皮质动脉组的高密度脂蛋白胆固醇（HDL-C）和HDL-C亚组分水平显著低于穿通动脉组。ICVD患者中HDL-C和高密度脂蛋白亚组分的降低量与梗死体积大小呈负相关。据信，测定高密度脂蛋白亚组分和载脂蛋白B的浓度并早期纠正脂蛋白代谢异常可能有助于预防或延缓中风。
