Li Wei, Zhao Lin, Sun Li-Tong, Xie Ze-Ping, Zhang Shu-Min, Yue Xi-Dian, Dai Sheng-Jun
School of Pharmaceutical Science, Yantai University Yantai 264005 P. R. China
School of Pharmaceutical Science, Binzhou Medical University Yantai 264003 P. R. China
RSC Adv. 2021 Sep 6;11(47):29684-29689. doi: 10.1039/d1ra05760j. eCollection 2021 Sep 1.
Two unique trinorlabdane diterpenoid alkaloids, forsyqinlingines A (1) and B (2), were isolated from the ripe fruits of . Their structures, including absolute stereochemical configurations, were fully elucidated from extensive spectroscopy experiments, single-crystal X-ray diffraction, and electronic circular dichroism (ECD). In addition, a plausible biosynthetic pathway for the formation of compounds 1 and 2 in was also proposed. , the two C-labdane diterpenoid alkaloids exhibited anti-inflammatory activities by inhibiting the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs), and antiviral activities against influenza A (H1N1) virus and respiratory syncytial virus (RSV).
从[具体植物名称]的成熟果实中分离出两种独特的三降贝壳杉烷二萜生物碱，福氏秦灵碱A（1）和B（2）。通过广泛的光谱实验、单晶X射线衍射和电子圆二色光谱（ECD），全面阐明了它们的结构，包括绝对立体化学构型。此外，还提出了[具体植物名称]中化合物1和2形成的一种合理生物合成途径。这两种C-贝壳杉烷二萜生物碱通过抑制大鼠多形核白细胞（PMNs）中β-葡萄糖醛酸酶的释放表现出抗炎活性，以及对甲型流感病毒（H1N1）和呼吸道合胞病毒（RSV）的抗病毒活性。
