Guilly M N, Kolb J P, Gosti F, Godeau F, Courvalin J C
Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette, France.
Exp Cell Res. 1990 Jul;189(1):145-7. doi: 10.1016/0014-4827(90)90267-e.
Lamins are major proteins of the nuclear envelope that are members of the intermediate filament protein family. In vertebrates, nuclei from differentiated tissues usually contain both lamins of the A and B subtypes, while embryonic tissues contain the B-type lamin only. We have examined the composition of the nuclear lamina in human B and T lymphocytes representative of distinct stages of lymphoid differentiation. We show here that, in both cell lineages, while lamin B is constitutively expressed at all stages of differentiation, A-type lamin expression is restricted to later developmental stages.
