Alkofahi A, Rupprecht J K, Liu Y M, Chang C J, Smith D L, McLaughlin J L
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Experientia. 1990 May 15;46(5):539-41. doi: 10.1007/BF01954260.
Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid gamma-lactone (acetogenin), was isolated from an ethanolic extract of the stem bark of Goniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK).
巨盘木素（I）是一种新型的四羟基-二-四氢呋喃脂肪酸γ-内酯（产乙酸素），通过活性导向分级分离法（卤虫致死试验）从大花哥纳香（番荔枝科）茎皮的乙醇提取物中分离得到。这种新化合物对人类肿瘤细胞具有极强的细胞毒性，能抑制马铃薯圆盘上的冠瘿瘤，并且在一项旨在检测抗有丝分裂剂的试验（9-ASK）中具有活性。
