Alkofahi A, Rupprecht J K, Smith D L, Chang C J, McLaughlin J L
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.
Experientia. 1988 Jan 15;44(1):83-5. doi: 10.1007/BF01960258.
Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid gamma-lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark of Goniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity of II was confirmed, and II is now also found to be weakly active against 3PS murine leukemia.
利用卤虫致死率进行活性导向分级分离，从藤春（番荔枝科）的巨型藤春胡克变种托马斯的茎皮乙醇提取物中分离出了一种新的四羟基-单-四氢呋喃脂肪酸γ-内酯（番荔枝内酯）——乔那霉素（I）。发现这种新化合物具有细胞毒性和杀虫活性，并能抑制马铃薯圆盘上冠瘿瘤的形成。还分离出了另一种已报道的单-四氢呋喃番荔枝内酯——番荔枝宁（II）；证实了II先前报道的9ASK（星形细胞瘤逆转）活性，并且现在还发现II对3PS小鼠白血病有微弱活性。
