Skin and Cancer Unit, The Ronald O. Perelman Department of Dermatology, New York University, New York, NY, USA.
Dermatitis. 2013 Mar-Apr;24(2):77-81. doi: 10.1097/DER.0b013e318284da45.
Fentichlor elicits high rates of positive photopatch test reactions despite its currently unknown clinical relevance.
The aims of this study were to provide a comprehensive review of fentichlor, to investigate the characteristics of patients with photosensitivity to fentichlor, and to explore the current uses of fentichlor.
A review of photopatch test studies involving fentichlor was performed. A retrospective chart review was conducted in patients with positive photopatch test reactions to fentichlor at our institution. Product inquiries were placed to manufacturers of fentichlor to elicit the current uses of fentichlor.
In selected photopatch test studies, positive reactions to fentichlor occurred in 0.0% to 11.8% of subjects. We found that 25 companies distribute or manufacture fentichlor worldwide, which includes 2 companies that sell 25-kg drums of fentichlor. The most common current uses of fentichlor are in research, in high throughput screening, and in antibacterial and antifungal creams.
Our review of selected photopatch test studies demonstrates that fentichlor remains a potent photosensitizing allergen worldwide. The bulk quantities of fentichlor available for sale and the current uses of fentichlor suggest that fentichlor may be currently incorporated into consumer products. We recommend that fentichlor remain in the standard series of photopatch test allergens.
尽管目前尚不清楚芬太尼氯的临床相关性，但它会引起很高的光贴试验阳性反应率。
本研究旨在全面综述芬太尼氯，研究对芬太尼氯光过敏的患者特征，并探讨芬太尼氯的当前用途。
对涉及芬太尼氯的光贴试验研究进行了回顾。对在我院进行光贴试验时对芬太尼氯呈阳性反应的患者进行了回顾性图表审查。向芬太尼氯的制造商发出产品查询，以了解芬太尼氯的当前用途。
在选定的光贴试验研究中，芬太尼氯的阳性反应率为 0.0%至 11.8%。我们发现，全球有 25 家公司分销或生产芬太尼氯，其中包括 2 家销售 25 公斤装芬太尼氯桶的公司。芬太尼氯的最常见当前用途是在研究、高通量筛选以及抗菌和抗真菌乳膏中。
我们对选定的光贴试验研究进行了回顾，结果表明芬太尼氯仍然是全球一种有效的光敏致敏原。芬太尼氯的大量供应和当前用途表明，芬太尼氯可能已被纳入消费产品。我们建议芬太尼氯仍保留在光贴试验过敏原的标准系列中。
