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本文引用的文献

1
Breast cancer-associated fibroblasts induce epithelial-to-mesenchymal transition in breast cancer cells.乳腺癌相关成纤维细胞诱导乳腺癌细胞发生上皮间质转化。
Endocr Relat Cancer. 2013 Jan 7;20(1):1-12. doi: 10.1530/ERC-12-0227. Print 2013 Feb.
2
The pancreas cancer microenvironment.胰腺癌微环境。
Clin Cancer Res. 2012 Aug 15;18(16):4266-76. doi: 10.1158/1078-0432.CCR-11-3114.
3
In vitro and in vivo prostate cancer metastasis and chemoresistance can be modulated by expression of either CD44 or CD147.无论是 CD44 还是 CD147 的表达都能调节前列腺癌的体外和体内转移及化疗耐药性。
PLoS One. 2012;7(8):e40716. doi: 10.1371/journal.pone.0040716. Epub 2012 Aug 3.
4
Role of emmprin in endometrial cancer.子宫内膜癌中 emmprin 的作用。
BMC Cancer. 2012 May 28;12:191. doi: 10.1186/1471-2407-12-191.
5
Expression of CD147, BIGH3 and Stathmin and their potential role as diagnostic marker in patients with urothelial carcinoma of the bladder.CD147、BIGH3 和 Stathmin 的表达及其作为膀胱癌患者诊断标志物的潜在作用。
Clin Chim Acta. 2012 Oct 9;413(19-20):1641-6. doi: 10.1016/j.cca.2012.05.005. Epub 2012 May 14.
6
Accessories to the crime: functions of cells recruited to the tumor microenvironment.肿瘤微环境中募集的细胞的功能：犯罪的帮凶。
Cancer Cell. 2012 Mar 20;21(3):309-22. doi: 10.1016/j.ccr.2012.02.022.
7
Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway.二聚化对于 HAb18G/CD147 通过 MAPK 通路促进肿瘤侵袭是必不可少的。
Biochem Biophys Res Commun. 2012 Mar 16;419(3):517-22. doi: 10.1016/j.bbrc.2012.02.049. Epub 2012 Feb 15.
8
Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma.环孢素 A 配体和受体 CD147 与舌鳞癌缺氧、血管生成、转移和预后的关系。
Histopathology. 2012 Apr;60(5):793-803. doi: 10.1111/j.1365-2559.2011.04130.x. Epub 2012 Feb 9.
9
Re-expression of miR-21 contributes to migration and invasion by inducing epithelial-mesenchymal transition consistent with cancer stem cell characteristics in MCF-7 cells.miR-21 的重新表达通过诱导上皮-间充质转化，促进 MCF-7 细胞的迁移和侵袭，与癌症干细胞特征一致。
Mol Cell Biochem. 2012 Apr;363(1-2):427-36. doi: 10.1007/s11010-011-1195-5. Epub 2011 Dec 21.
10
Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.单羧酸转运蛋白 4（MCT4）和 CD147 的过表达与前列腺癌的不良预后相关。
BMC Cancer. 2011 Jul 25;11:312. doi: 10.1186/1471-2407-11-312.

EMMPRIN/CD147 在乳腺癌细胞将静止成纤维细胞转化为癌相关成纤维细胞中的新作用。

A novel role of EMMPRIN/CD147 in transformation of quiescent fibroblasts to cancer-associated fibroblasts by breast cancer cells.

机构信息

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Cancer Lett. 2013 Jul 28;335(2):380-6. doi: 10.1016/j.canlet.2013.02.054. Epub 2013 Mar 6.

DOI:10.1016/j.canlet.2013.02.054
PMID:23474495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3927232/
Abstract

We tested the novel hypothesis that EMMPRIN/CD147, a transmembrane glycoprotein overexpressed in breast cancer cells, has a previously unknown role in transforming fibroblasts to cancer-associated fibroblasts, and that cancer-associated fibroblasts in turn induce epithelial-to-mesenchymal transition of breast cancer cells. Co-culture of fibroblasts with breast cancer cells or treatment of fibroblasts with breast cancer cell conditioned culture medium or recombinant EMMPRIN/CD147 induced expression of α-SMA in the fibroblasts in an EMMPRIN/CD147-dependent manner and promoted epithelial-to-mesenchymal transition of breast cancer cells and enhanced cell migration potential. These findings support a novel role of EMMPRIN/CD147 in regulating the interaction between cancer and stroma.

摘要

我们检验了一个新假说，即跨膜糖蛋白 EMMPRIN/CD147 在乳腺癌细胞中过表达，它在将成纤维细胞转变成癌相关成纤维细胞方面具有未知的作用，而癌相关成纤维细胞又反过来诱导乳腺癌细胞发生上皮间质转化。成纤维细胞与乳腺癌细胞共培养或用乳腺癌细胞条件培养基或重组 EMMPRIN/CD147 处理成纤维细胞，以 EMMPRIN/CD147 依赖性方式诱导成纤维细胞中 α-SMA 的表达，并促进乳腺癌细胞的上皮间质转化和增强细胞迁移能力。这些发现支持 EMMPRIN/CD147 在调节癌症与基质之间相互作用方面的新作用。